Limitation of Block Level VMDK Backups

Block level vmdk backups have limitations that will GET YOU.  Backup Exec and Veeam both have the ability to backup the vmdk files in a VMware environment and still retain enough information in the backup set to do individual file level restores.  However, both products will ONLY work if you have vmdk disks partitioned using the MBR (Master Boot Record) type tables and NOT the more modern GPT (Guid Partition Table) structure.

Networking Veeam Backup Exec VMware